Arterial and mixed venous xenon blood concentrations in pigs during wash-in of inhalational anaesthesia

• Published in: British journal of anaesthesia : BJA Vol. 87; no. 3; pp. 497 - 498
• Main Authors: Nalos, M., Wachter, U., Pittner, A., Georgieff, M., Radermacher, P., Froeba, G.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-09-2001; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: anaesthestic techniques; anaesthestic techniques, inhalation; anaesthetics; anaesthetics, gases, xenon; Anesthesia, Inhalation - methods; Anesthetics, Inhalation - blood; Anesthetics, Inhalation - pharmacokinetics; Anesthetics. Neuromuscular blocking agents; Animals; Biological and medical sciences; gases; inhalation; Medical sciences; Neuropharmacology; pharmacokinetics; pharmacokinetics, xenon; Pharmacology. Drug treatments; pig; Swine; xenon; Xenon - blood; Xenon - pharmacokinetics; anaesthetics, gases, xenon; anaesthestic techniques, inhalation; pharmacokinetics, xenon; pig; anaesthestic techniques, inhalation; anaesthetics, gases, xenon; pharmacokinetics, xenon; pig; Xenon; General anesthesia; Inhalation; Pig; Mixed venous blood; Expired gas; Arterial blood; Vertebrata; Mammalia; General anesthetic; Animal; Artiodactyla; Pharmacokinetics; Ungulata
• ISSN: 0007-0912; 1471-6771
• DOI: 10.1093/bja/87.3.497

There are no data available on the kinetics of blood concentrations of xenon during the wash-in phase of an inhalation anaesthesia aiming at 1 MAC end-expiratory concentration. Therefore, we anaesthetized eight pigs with continuous propofol and fentanyl and measured arterial, mixed venous and end-expiratory xenon concentrations by gas chromatography–mass spectrometry 1, 2, 3, 4, 5, 7, 10, 15, 20, 30, 60 and 120 min after starting the anaesthetic gas mixture [67% xenon/33% oxygen; 3 litre min−1 during the first 10 min, thereafter minimal flow with 0.48 (sd 0.03) litre min−1]. End-expiratory xenon concentrations plateaued (defined as <5% change from the preceding value) at 64 (6) vol% after 7 min, and arterial and mixed venous xenon concentrations after 5 and 15 min respectively. The highest arterio-venous concentration difference occurred after 3 min. Using the Fick principle, we calculated a mean xenon uptake of 3708 (829) and 9977 (3607) ml after 30 and 120 min respectively.