Effects of oral propranolol on the resistive and pulsatility indices of major abdominal vasculatures in domestic short-haired cats

• Published in: Veterinary medicine and science Vol. 9; no. 4; pp. 1456 - 1459
• Main Authors: Amini Masouleh, Shima, Nasrollahzadeh Masouleh, Mohammad, Vazir, Bita, Bokaie, Saied
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-07-2023; John Wiley and Sons Inc; Wiley
• Subjects: Abdomen; Animals; Aorta; Blood Flow Velocity - veterinary; Blood pressure; CATS; Coronary vessels; Doppler effect; Doppler ultrasonography; Drug dosages; Female; Hypertension; Hyperthyroidism; Kidney diseases; Liver cirrhosis; Liver diseases; Male; Males; Novellas; Oral administration; Original; Portal vein; Propranolol; Pulsatile Flow; pulsatility index; resistive index; Ultrasonic imaging; Ultrasonography, Doppler - veterinary; Veins & arteries; Velocity; Doppler ultrasonography; resistive index; pulsatility index; propranolol
• ISSN: 2053-1095; 2053-1095
• DOI: 10.1002/vms3.1176

No study has been performed regarding the effects of oral administration of propranolol on pulse-wave spectral Doppler indices of major abdominal vessels in healthy adult cats.
The objective of this study was to assess the pulse-wave spectral Doppler indices of abdominal aorta, caudal vena cava, and portal vein in clinically normal adult domestic short-haired (DSH) cats, before and after propranolol ingestion.
Twenty intact adult client-owned DSH cats were evaluated (10 males and 10 females). A duplex Doppler ultrasonography machine with a 10-MHz frequency linear transducer was used. Peak systolic velocity, end-diastolic velocity (EDV), resistive index (RI), pulsatility index (PI), and pressure gradient were measured. All the cats received 1 mg/kg of propranolol tablet, and after 2 h, ultrasonography measurements were repeated.
The mean RI of the aorta and caudal vena cava significantly decreased in male cats following oral administration of propranolol after 2 h (p = 0.03, p = 0.02). In the caudal vena cava, the PI decreased from 2.98 ± 0.62 to 1.15 ± 0.19 post-propranolol ingestion (p = 0.01). The mean EDV in the caudal vena cava of males and portal veins of females significantly decreased after propranolol ingestion (p = 0.04, p = 0.02).
This study showed that propranolol decreased the PI of the aorta and PI and RI of the caudal vena cava in healthy normal cats 2 h post-propranolol ingestion at the dosage of 1 mg/kg.