Loneliness in adolescence and prescription of psychotropic drugs in adulthood: 23-year longitudinal population-based and registry study

• Published in: BJPsych open Vol. 10; no. 2; p. e61
• Main Authors: Rodríguez-Cano, Rubén, Lotre, Karianne, von Soest, Tilmann, Rognli, Eline Borger, Bramness, Jørgen Gustav
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 11-03-2024; Royal College of Psychiatrists
• Subjects: Antidepressants; bipolar disorder; Child and Adolescent; drug prescriptions; Loneliness; Loneliness trajectories; Longitudinal studies; Mental disorders; Prescription drugs; psychotic disorders; Psychotropic drugs; Students; Norway; drug prescriptions; bipolar disorder; psychotic disorders; Loneliness trajectories; mental disorders
• ISSN: 2056-4724; 2056-4724
• DOI: 10.1192/bjo.2024.22

The role of adolescent loneliness in adult mental health and prescriptions of psychotropic drugs remains underexplored.
We aim to determine whether (a) experiencing loneliness in adolescence and (b) changes in loneliness from adolescence to adulthood are prospectively associated with prescriptions for a variety of psychotropic drugs in adulthood.
We used data from a Norwegian population-based sample with 2602 participants, collected across four waves between 1992 and 2006. Loneliness was assessed at each wave, with survey data linked to medicinal drug prescription records from the Norwegian Prescription Database. We identified prescription histories of antipsychotics, mood stabilisers, antidepressants and benzodiazepines from 2007 to 2015, for each participant. We use latent growth curve analyses to model the relationship of adolescent loneliness and loneliness change from adolescence to adulthood, with subsequent psychotropic drugs prescription.
Adolescents with heightened loneliness, and adolescents whose loneliness increased into young adulthood, had a greater likelihood of being prescribed antipsychotics, mood stabilisers and antidepressants in adulthood. These associations remained significant after adjustment for confounders such as sociodemographic characteristics, conduct problems, substance use and mental health problems.
Loneliness in adolescence and its adverse development over a span of 15 years was linked to higher risk of receiving prescriptions for antipsychotics, mood stabilisers and antidepressants later in life. The findings may indicate that loneliness increases the risk for developing psychotic disorders, bipolar disorders and major depression.