ROCK-Generated Contractility Regulates Breast Epithelial Cell Differentiation in Response to the Physical Properties of a Three-Dimensional Collagen Matrix

Breast epithelial cells differentiate into tubules when cultured in floating three-dimensional (3D) collagen gels, but not when the cells are cultured in the same collagen matrix that is attached to the culture dish. These observations suggest that the biophysical properties of collagenous matrices...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 163; no. 3; pp. 583 - 595
Main Authors:	Wozniak, Michele A., Desai, Radhika, Solski, Patricia A., Der, Channing J., Keely, Patricia J.
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 10-11-2003 The Rockefeller University Press
Subjects:	Amino Acid Sequence - genetics Breasts Cell Adhesion - drug effects Cell Adhesion - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Cell division Cell Division - drug effects Cell Division - physiology Cell growth Cell Line Cell Movement - drug effects Cell Movement - physiology Cell Size - drug effects Cell Size - physiology Cells Cellular biology Collagen - pharmacology Collagens Cultured cells Down-Regulation - drug effects Down-Regulation - physiology Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - physiology Extracellular Matrix - metabolism Female Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Focal adhesions Focal Adhesions - drug effects Focal Adhesions - metabolism Gels Gels - pharmacology Humans Intracellular Signaling Peptides and Proteins Mammary Glands, Human - cytology Mammary Glands, Human - growth & development Phosphorylation Phosphorylation - drug effects Physiological regulation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism rho GTP-Binding Proteins - metabolism rho-Associated Kinases
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