Overhydration and low serum prealbumin predict peritoneal dialysis-related peritonitis in continuous ambulatory peritoneal dialysis patients

• Published in: BMC nephrology Vol. 21; no. 1; p. 512
• Main Authors: Dao Bui Quy, Quyen, Pham Ngoc Huy, Tuan, Nguyen Duc, Loc, Pham Van, My, Nguyen Huu, Dung, Nguyen Duy, Toan, Tran Viet, Tien, Do, Quyet, Le Viet, Thang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25-11-2020; BioMed Central
• Subjects: Anemia; Body composition; Catheters; Complications and side effects; Continuous ambulatory peritoneal dialysis; Creatinine; Effluents; Health aspects; Infections; Malnutrition; Mortality; Nephrology; Patients; Peritoneal dialysis; Peritoneum; Peritonitis; Renal replacement therapy; Risk factors; Serum albumin; Water-electrolyte imbalances; Vietnam; Serum prealbumin; Overhydration; Continuous ambulatory peritoneal dialysis; Peritoneal dialysis; Peritonitis
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-020-02178-w

In this study, we focused on the role of overhydration (OH) and low serum prealbumin concentration in predicting peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 3-year period.
We measured serum prealbumin concentration and OH by body composition monitor in 278 CAPD patients (159 males and 119 females) with a mean age of 46 years and a median peritoneal dialysis (PD) duration of 21 months. Cases of PD-related peritonitis were collected over 3 years.
After the 3-year follow-up, 44 patients were diagnosed with PD-related peritonitis (15.8%). Low education, serum glucose, prealbumin, and OH were independent risk factors for predicting peritonitis over 36 months in CAPD patients. Based on the ROC curve model and Kaplan-Meier analysis, we realized that low prealbumin and high OH were independent predictors of 3-year peritonitis in CAPD patients (Prealbumin: AUC = 0.838, cut-off value = 32.5 mg/dL, Se = 90.9%, Sp = 32.9%; OH: AUC = 0.851, cut-off value = 1.33 L, Se = 79.5%, Sp = 85.5%; and log-rank test p <  0.001, respectively).
Overhydration and low serum prealbumin were the independent predictors of PD-related peritonitis in CAPD patients.