Effect of Intraperitoneal Curcumin Instillation on Postoperative Peritoneal Adhesions

• Published in: Medical principles and practice Vol. 24; no. 2; pp. 153 - 158
• Main Authors: Türkoğlu, Ahmet, Gül, Mesut, Yuksel, Hatice Kurt, Alabalik, Ulas, Ülger, Burak Veli, Uslukaya, Omer, Avci, Yahya
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01-01-2015
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Cecum - drug effects; Cecum - pathology; Curcumin - administration & dosage; Curcumin - pharmacology; Disease Models, Animal; Hydroxyproline - analysis; Infusions, Parenteral; Male; Original Paper; Peritoneum - drug effects; Peritoneum - pathology; Postoperative Complications - prevention & control; Random Allocation; Rats; Rats, Wistar; Tissue Adhesions - prevention & control; Adhesion formation; Curcumin; Intraperitoneal adhesion
• ISSN: 1011-7571; 1423-0151
• DOI: 10.1159/000369020

Objective: The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Methods: Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. Results: There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 ± 11.8 µg/mg) and the curcumin (63.8 ± 13.9 µg/mg) group compared to the control group (85.7 ± 22.1 µg/mg; p < 0.05). Conclusion: These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation.