Identification of a polypeptide associated with the malignant phenotype in acute leukemia

• Published in: The Journal of biological chemistry Vol. 263; no. 26; pp. 12813 - 12815
• Main Authors: Hanash, S M, Strahler, J R, Kuick, R, Chu, E H, Nichols, D
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 15-09-1988; American Society for Biochemistry and Molecular Biology
• Subjects: Acute Disease; acute lymphatic leukemia; Biological and medical sciences; Cell Differentiation; Cell differentiation, maturation, development, hematopoiesis; Cell Division; Cell physiology; Electrophoresis, Polyacrylamide Gel; Fundamental and applied biological sciences. Psychology; Humans; Leukemia - metabolism; man; Molecular and cellular biology; Peptides - metabolism; Phenotype; Human; Cell proliferation; Gel electrophoresis; Hematopoiesis; Polypeptide; Leukemia; Two dimensional electrophoresis; Cell differentiation; Cell transformation
• ISSN: 0021-9258; 1083-351X
• DOI: 10.1016/S0021-9258(18)37630-0

A novel polypeptide, designated p18, was detected in a variety of hematopoietic cells by two-dimensional polyacrylamide gel electrophoresis. Quantitative analysis of p18 indicated its occurrence in a substantially greater amount in acute leukemia relative to nonleukemic cells. The increased amount of p18 in leukemia could not be explained on the basis of specific lineage, differentiation stage, or cell proliferation and thus appears to be a part of the malignant phenotype of the leukemic cells.