New furanones from the plant endophytic fungus Pestalotiopsis besseyi

• Published in: Molecules (Basel, Switzerland) Vol. 17; no. 12; pp. 14015 - 14021
• Main Authors: Liu, Haitao, Liu, Shuchun, Guo, Liangdong, Zhang, Yonggang, Cui, Langjun, Ding, Gang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27-11-2012; MDPI
• Subjects: Alternaria - drug effects; Anti-HIV Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; bioactivity; Cell Line; endophytes; Furans - chemistry; Furans - isolation & purification; Furans - pharmacology; Herbal medicine; HIV Infections - drug therapy; HIV-1 - drug effects; Humans; Magnetic Resonance Spectroscopy; Metabolites; Molecular Structure; Pathogens; pestalafuranones A– Pestalotiopsis besseyi; Plants - chemistry; Plants - drug effects; Plants - microbiology; Verticillium - drug effects; Xylariales - chemistry; Beijing China; China
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules171214015

Pestalafuranones A-E (compounds 1-5), five new 2(5H)-furanones, have been isolated from cultures of an isolate of Pestalotiopsis besseyi. The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic data and HRESIMS experiments. Pestalafuranones A-C (compounds 1-3) displayed weak inhibitory effects against HIV-1 replication in C8166 cells, whereas pestalafuranones D (4) and E (5) showed moderate antifungal activity against the plant pathogens Verticillium dahiae and Alternaria longipes.