Occurrence of the t(2;5)(p23;q35) in Non-Hodgkin's Lymphoma

• Published in: Blood Vol. 87; no. 9; pp. 3860 - 3868
• Main Authors: Weisenburger, Dennis D., Gordon, Bruce G., Vose, Julie M., Bast, Martin A., Chan, Wing C., Greiner, Timothy C., Anderson, James R., Sanger, Warren G.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01-05-1996; The Americain Society of Hematology
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor; Child; Child, Preschool; Chromosome Aberrations; Genetic Markers; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Non-Hodgkin - genetics; Lymphoma, Non-Hodgkin - pathology; Lymphoma, Non-Hodgkin - physiopathology; Medical sciences; Middle Aged; Chromosomal aberration; Translocation; Prognosis; Occurrence frequency; Malignant hemopathy; Grouping; Large cell lymphoma; Non Hodgkin lymphoma; Phenotype; Abnormal chromosome B5; Lymphoproliferative syndrome; Abnormal chromosome A2; Abnormal chromosome
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V87.9.3860.bloodjournal8793860

Primary CD30(Ki-1)-positive anaplastic large-call lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30-positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study.