Probiotics and Intestinal Colonization by Vancomycin-Resistant Enterococci in Mice and Humans

• Published in: Journal of Clinical Microbiology Vol. 48; no. 7; pp. 2595 - 2598
• Main Authors: Vidal, Magali, Forestier, Christiane, Charbonnel, Nicolas, Henard, Sandrine, Rabaud, Christian, Lesens, Olivier
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-07-2010; American Society for Microbiology (ASM)
• Subjects: Aged; Aged, 80 and over; Animals; Bacteriology; Biological and medical sciences; Carrier State - microbiology; Carrier State - physiopathology; Colony Count, Microbial; Disease Models, Animal; Double-Blind Method; Electrophoresis, Agar Gel; Enterococcus - drug effects; Escherichia coli; Feces - microbiology; Fundamental and applied biological sciences. Psychology; Humans; Lactobacillus rhamnosus; Mice; Microbiology; Middle Aged; Miscellaneous; Phylogeny; Pilot Projects; Probiotics - therapeutic use; Vancomycin - adverse effects; Vancomycin - pharmacology; Vancomycin Resistance - drug effects; Enterococcus; Human; Probiotic; Lactic acid bacteria; Peptides; Digestive system; Rodentia; Gut; Vancomycin; Resistance; Streptococcaceae; Vertebrata; Antibiotic; Mammalia; Mouse; Glycopeptide; Polypeptide; Bacteria; Micrococcales; Antibacterial agent
• ISSN: 0095-1137; 1098-660X
• DOI: 10.1128/JCM.00473-10

We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.