Clinical and molecular correlates of the ASPECTS in the acute phase of stroke

• Published in: Arquivos de neuro-psiquiatria Vol. 78; no. 5; pp. 262 - 268
• Main Authors: MOURÃO, Aline Mansueto, VICENTE, Laélia Cristina Caseiro, ABREU, Mery Natali Silva, SANT’ANNA, Romeu Vale, DE MEIRA, Fidel Castro Alves, XAVIER, Rodrigo Menezes de Brito, TANURE, Marco Túlio de Azevedo, VIEIRA, Erica Leandro Marciano, DE SOUZA, Leonardo Cruz, MIRANDA, Aline Silva de, RACHID, Milene Alvarenga, TEIXEIRA, Antônio Lucio
• Format: Journal Article
• Language: English
• Published: Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Thieme Revinter Publicações Ltda 01-05-2020; Arquivos de Neuro-Psiquiatria; Academia Brasileira de Neurologia - ABNEURO; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: Adiponectin; Biomarkers; brain ischemia; Brain-derived neurotrophic factor; Cognitive ability; IL-1β; Ischemia; neurologic examination; Neurological complications; neurology; NEUROSCIENCES; Plasma levels; prognosis; PSYCHIATRY; Stroke; Thrombolysis; Vascular cell adhesion molecule 1; Vascular endothelial growth factor; Neurology; Neurologia; Brain Ischemia; Neurologic Examination; Prognosis; Exame Neurológico; Isquemia Encefálica; Prognóstico; Biomarkers; Biomarcadores
• ISSN: 0004-282X; 1678-4227; 1678-4227
• DOI: 10.1590/0004-282X20200001

ABSTRACT
Background:
The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to the ischemic stroke.
Objective:
To investigate the association between peripheral biomarkers with the Alberta Stroke Program Early CT Score (ASPECTS) in individuals after ischemic stroke.
Methods:
Patients over 18 years old with acute ischemic stroke were enrolled in this study. No patient was eligible for thrombolysis. The patients were submitted to non-contrast CT in the first 24 hours of admission, being the Alberta Stroke Program Early CT Score and clinical and molecular evaluations applied on the same day. The National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale and the Mini-Mental State Examination for clinical evaluation were also applied to all subjects. Plasma levels of BDNF, VCAM-1, VEGF, IL-1β, sTNFRs and adiponectin were determined by ELISA.
Results:
Worse neurological impairment (NIHSS), cognitive (MEEM) and functional (Rankin) performance was observed in the group with changes in the NCTT. Patients with NCTT changes also exhibited higher levels of IL-1β and adiponectin. In the linear multivariate regression, an adjusted R coefficient of 0.515 was found, indicating adiponectin and NIHSS as independent predictors of ASPECTS.
Conclusion:
Plasma levels of adiponectin are associated with the ASPECTS scores.