Gender effect on non-motor symptoms in Parkinson's disease: A men more at risk?

• Published in: Parkinsonism & related disorders Vol. 35; pp. 69 - 74
• Main Authors: Nicoletti, A, Vasta, R, Mostile, G, Nicoletti, G, Arabia, G, Iliceto, G, Lamberti, P, Marconi, R, Morgante, L, Barone, P, Quattrone, A, Zappia, M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-02-2017
• Subjects: Aged; Case-Control Studies; Depressive Disorder; Female; Gastrointestinal Diseases - diagnosis; Gastrointestinal Diseases - physiopathology; Gastrointestinal Diseases - psychology; Gender effect; Humans; Male; Middle Aged; Neurology; Non-motor symptoms; Parkinson Disease - diagnosis; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Parkinson's disease/Parkinsonism; Risk Factors; Sex Characteristics; Sleep Wake Disorders - diagnosis; Sleep Wake Disorders - physiopathology; Sleep Wake Disorders - psychology; Case-control studies; Non-motor symptoms; Gender effect; Parkinson's disease/Parkinsonism
• ISSN: 1353-8020; 1873-5126
• DOI: 10.1016/j.parkreldis.2016.12.008

Abstract Introduction Several gender differences have been reported in Parkinson's Disease (PD). We evaluated the burden of non-motor symptoms (NMS) in PD and the possible gender differences in their occurrence. Methods The FRAGAMP study is a large multicenter case-control study. PD patients and controls underwent a face-to-face interview and a neurological examination performed by trained neurologists. Presence of NMS was investigated using a standardized questionnaire; cognitive impairment and depression were assessed using the Mini Mental State Examination and the Hamilton Depression Rating Scale respectively. Results 585 PD patients (59.5% men) and 481 controls (34.9% men) were enrolled in the study. All NMS were significantly more frequent among PD patients than controls. PD women showed a significantly higher frequency of depression and urinary disturbances than parkinsonian men; a close frequency among PD women and men was recorded for hallucination, cognitive impairment and sleep disorders. Nonetheless, with respect to the control population, according to logistic regression stratified by sex and adjusted by age, PD men showed a stronger positive significant association with almost all NMS compared to women, excepting for urinary disturbances. The strongest association among PD men was recorded for cognitive impairment (adjusted OR 5.44 for men and 2.82 for women) and depression (adjusted OR 30.88 for men and 12.72 for women). Conclusions With respect to the general population, presence of NMS was stronger associated with male gender. Our data suggest that the presence of NMS among PD men is more strictly due to the neurodegenerative processes related to PD.