MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes

MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes

Highlights • MCPIP1 level is decreased during first hours after treatment of human primary keratinocytes with UVB light, then, 6 to 12 h after UVB exposure its level grows up above the level of the untreated cells. • Regulation of MCPIP1 expression is driven by NF-κB, ERK1/2 and p38. • Diminished le...

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Bibliographic Details
Published in:Journal of dermatological science Vol. 87; no. 1; pp. 10 - 18
Main Authors: Bugara, Beata, Konieczny, Piotr, Wolnicka-Glubisz, Agnieszka, Eckhart, Leopold, Fischer, Heinz, Skalniak, Lukasz, Borowczyk-Michalowska, Julia, Drukala, Justyna, Jura, Jolanta
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-07-2017
Subjects:
Apoptosis
Cell viability
Cells, Cultured
Dermatology
Humans
Inflammation - etiology
Interleukin-8 - genetics
Keratinocytes
Keratinocytes - radiation effects
MCPIP1
NF-kappa B - physiology
p38 Mitogen-Activated Protein Kinases - physiology
Ribonucleases - analysis
Ribonucleases - genetics
Ribonucleases - physiology
Signal Transduction - physiology
Signaling pathways
Transcription Factors - analysis
Transcription Factors - genetics
Transcription Factors - physiology
Ultraviolet Rays
UVB
UVB
Signaling pathways
Keratinocytes
Cell viability
MCPIP1
Apoptosis
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Summary:Highlights • MCPIP1 level is decreased during first hours after treatment of human primary keratinocytes with UVB light, then, 6 to 12 h after UVB exposure its level grows up above the level of the untreated cells. • Regulation of MCPIP1 expression is driven by NF-κB, ERK1/2 and p38. • Diminished level of MCPIP1 in UVB-treated keratinocytes correlates with increased metabolism, enhanced release of proinflammatory mediators and activation of antiapoptotic factors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2017.03.013