Augmenting amisulpride with clozapine had led to unmasking of akathisia

• Published in: Industrial psychiatry journal Vol. 21; no. 2; pp. 152 - 154
• Main Authors: Ray, Anirban, Munshi, Santanu
• Format: Journal Article
• Language: English
• Published: India Medknow Publications 01-07-2012; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adverse reaction; akathisia; Antipsychotics; augmentation; Case Report; Case reports; Clozapine; Drug dosages; Drug interactions; Drug withdrawal; Dystonia; Medical research; Patients; Psychotropic drugs; Remission (Medicine); Schizophrenia; akathisia; Adverse reaction; schizophrenia; augmentation
• ISSN: 0972-6748; 0976-2795
• DOI: 10.4103/0972-6748.119638

Amisulpride is a newer antipsychotic, which is very effective on its own, as well as augmenting other antipsychotic clozapine, which is an effective molecule for treatment resistant schizophrenia. In most cases, amisulpride is added on, in partial responders to clozapine. Here a case is reported where clozapine was added on, in an amisulpride partial responder but this produced side effect and had to be discontinued. The case later responded to clozapine alone. It has been discussed about possible reasons of this finding. It has also been suggested if sequence of introduction of medication is critical regarding getting the desired effect of the augmentation strategy.