Serum adiponectin and resistin levels in major depressive disorder

• Published in: Acta psychiatrica Scandinavica Vol. 121; no. 3; pp. 209 - 215
• Main Authors: Lehto, S. M., Huotari, A., Niskanen, L., Tolmunen, T., Koivumaa-Honkanen, H., Honkalampi, K., Ruotsalainen, H., Herzig, K.-H., Viinamäki, H., Hintikka, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-03-2010; Blackwell
• Subjects: adiponectin; Adiponectin - blood; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Blood tests; Cardiology. Vascular system; Comparative studies; Coronary Disease; Coronary heart disease; Demography; Depression; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Female; Heart; Humans; Inflammatory diseases; Life Style; major depressive disorder; Male; Medical sciences; Mental depression; metabolic syndrome; metabolic syndrome, resistin; Middle Aged; Mood disorders; Overweight; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; resistin; Resistin - blood; Severity of Illness Index; Socioeconomic Factors; Endocrinopathy; Mood disorder; Human; Metabolic diseases; Cardiovascular disease; Depression; Adipokine; Metabolic syndrome; Coronary heart disease; Adiponectin; major depressive disorder; Cross sectional study; Resistin
• ISSN: 0001-690X; 1600-0447
• DOI: 10.1111/j.1600-0447.2009.01463.x

Lehto SM, Huotari A, Niskanen L, Tolmunen T, Koivumaa‐Honkanen H, Honkalampi K, Ruotsalainen H, Herzig K‐H, Viinamäki H, Hintikka J. Serum adiponectin and resistin levels in major depressive disorder.
Objective:  To examine the role of the adipose‐tissue‐derived low‐grade inflammation markers adiponectin and resistin in major depressive disorder (MDD) in a population‐based sample.
Method:  Serum levels of adiponectin and resistin were measured from 70 DSM‐IV MDD subjects and 70 healthy controls. Depression severity was assessed with the 29‐item Hamilton Depression Rating Scale.
Results:  The MDD group had lowered serum adiponectin levels. Regression modelling with adjustments for age, gender, overweight, several socioeconomic and lifestyle factors, coronary heart disease and metabolic syndrome showed that each 5.0 μg/ml decrease in serum adiponectin increased the likelihood of MDD by approximately 20% (P = 0.01). The resistin levels correlated with atypical (P = 0.02), but not with typical depressive symptoms (P = 0.12).
Conclusion:  Our findings suggest that the lowered adiponectin levels in MDD are depression‐specific and not explained by conventional low adiponectin‐related factors such as such as coronary heart disease and metabolic disorders.