Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential

• Published in: International journal of nanomedicine Vol. 17; pp. 1951 - 1970
• Main Authors: Abdellatif, Ahmed A H, Younis, Mahmoud A, Alsharidah, Mansour, Al Rugaie, Osamah, Tawfeek, Hesham M
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-05-2022; Dove; Dove Medical Press
• Subjects: Biomedical engineering; biosensors; clinical translation; clinical trials; Drug delivery systems; Drugs; in vivo imaging; photodynamic therapy; quantum dots; Review; Semiconductors; Technology application; Vehicles; quantum dots; in vivo imaging; biosensors; clinical trials; clinical translation; photodynamic therapy
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/ijn.s357980

Despite the massive advancements in the nanomedicines and their associated research, their translation into clinically-applicable products is still below promises. The latter fact necessitates an in-depth evaluation of the current nanomedicines from a clinical perspective to cope with the challenges hampering their clinical potential. Quantum dots (QDs) are semiconductors-based nanomaterials with numerous biomedical applications such as drug delivery, live imaging, and medical diagnosis, in addition to other applications beyond medicine such as in solar cells. Nevertheless, the power of QDs is still underestimated in clinics. In the current article, we review the status of QDs in literature, their preparation, characterization, and biomedical applications. In addition, the market status and the ongoing clinical trials recruiting QDs are highlighted, with a special focus on the challenges limiting the clinical translation of QDs. Moreover, QDs are technically compared to other commercially-available substitutes. Eventually, we inspire the technical aspects that should be considered to improve the clinical fate of QDs.