Intravascular Ultrasound-Guidance Is Associated With Lower Cardiovascular Mortality and Myocardial Infarction for Drug-Eluting Stent Implantation　― Insights From an Updated Meta-Analysis of Randomized Trials

• Published in: Circulation Journal Vol. 83; no. 6; pp. 1410 - 1413
• Main Authors: Elgendy, Islam Y., Mahmoud, Ahmed N., Elgendy, Akram Y., Mintz, Gary S.
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 24-05-2019
• Subjects: Drug-eluting stents; Intravascular ultrasound; Meta-analysis; Intravascular ultrasound; Drug-eluting stents; Meta-analysis
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-19-0209

Background:Randomized trials have been underpowered to determine an effect of intravascular ultrasound (IVUS) guidance on hard outcomes for drug-eluting stent (DES) implantation.Methods and Results:Randomized trials that compared IVUS guidance vs. angiographic guidance for DES implantation were included; 10 trials with 5,060 patients. IVUS guidance was associated with a lower incidence of cardiovascular death (odds ratio [OR] 0.44, 95% CI 0.26–0.75), and myocardial infarction (OR 0.55, 95% CI 0.32–0.94).Conclusions:IVUS-guidance is associated with a lower incidence of cardiovascular death and myocardial infarction in the era of DES. These findings should encourage operators to use IVUS more often.