Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy

• Published in: Rheumatology (Oxford, England) Vol. 38; no. 6; pp. 564 - 567
• Main Authors: ROLF, C, ENGSTRÖM, B, BEAUCHARD, C, JACOBS, L. D, LE LIBOUX, A
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-06-1999; Oxford Publishing Limited (England)
• Subjects: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Arthroscopy; Biological and medical sciences; Casts, Surgical; Endoscopy; Female; General pharmacology; Humans; Investigative techniques, diagnostic techniques (general aspects); Ketoprofen - administration & dosage; Ketoprofen - pharmacokinetics; Knee Joint - chemistry; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Synovial Fluid - chemistry; Tissue Distribution; Knee; Human; Prostaglandin-endoperoxide synthase; Enzyme; Oral administration; Enzyme inhibitor; Reservoir; Ketoprofen; Non steroidal antiinflammatory agent; Tissue; Chemotherapy; Absorption; Arthroscopy; Treatment; Intraarticular administration; Distribution; Arylpropionic acid derivatives; Plaster; Endoscopy; Oxidoreductases; Kinetics
• ISSN: 1462-0324; 1462-0332
• DOI: 10.1093/rheumatology/38.6.564

The primary objective of this study was to assess the kinetics of ketoprofen in synovial fluid and intra-articular tissues in relation to plasma. The secondary objective was to study whether intra-articular tissues act as reservoirs.
The ketoprofen concentration was analysed in plasma, synovial fluid and intra-articular tissues after single application of a 30 mg plaster (n = 40), multiple applications for 5 days (n = 30) or oral intake of 50 mg (n = 30) in patients undergoing knee arthroscopy.
Median CMax values after topical application were 12.8 ng/ml in synovial fluid, 56.7 ng/g in synovial tissue, 349.3 ng/g in meniscus and 568.9 ng/g in cartilage.
Topical applications of ketoprofen allow the attainment of high intra-articular tissue concentrations.