Results of Excision of Unknown Papillary Neoplasms Detected on Core Biopsy

• Published in: European journal of breast health Vol. 17; no. 3; pp. 258 - 264
• Main Authors: Uğur Kılınç, Ayşe Nur, Bayramoğlu, Zeynep, Ünlü, Yaşar, Baran, Nahide, Altunkeser, Ayşegül, Aksoy, Nergis, Eryılmaz, Mehmet Ali, Öztürk Yıldırım, Elif Nur
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Publishing 01-07-2021; Galenos Publishing House
• Subjects: breast neoplasm; core biopsy; Original; papillary neoplasm; core biopsy; papillary neoplasm; Breast neoplasm
• ISSN: 2587-0831; 2587-0831
• DOI: 10.4274/ejbh.galenos.2021.6101

This study aimed to find out valuable parameters that predict the nature of breast papillary lesions before excision, and we compared our results with those in the literature.
We reviewed the medical records and pathology slides of patients diagnosed with papillary neoplasm after undergoing a core-needle biopsy between 2010 and 2020, who, subsequently, underwent surgical excision in a single tertiary care institution. The core biopsy results and pathology results of excision materials were compared with the radiological, pathological, and demographic findings.
A total of 51 patients were included in the study. According to the excision results, the patients were divided into two groups: the atypical group, which included 20 patients (39.3%), and the benign group, which included 31 patients (61.7%). The results of the core biopsy showed that the loss of myoepithelial cell layer was identified in 18 patients in the atypical group, while it was present in all patients in the benign group. Tumor sizes were larger and patient ages were older in the atypical group compared with the benign group. No significant difference was found between atypical and benign groups in terms of breast imaging-reporting and data system (BI-RADS) classification and location (right vs left; central vs peripheral). The upgrade rate was between 0% and 16% in literature, while it was 4% in our study.
There is no consensus on whether patients diagnosed with papillary neoplasia as a result of core biopsy will undergo excision. According to our results, patients with following criteria should have their lesions excised: those who are advanced in age, those who are diagnosed with a papillary lesion as a result of core biopsies with loss of myoepithelial cell layer, and those who are diagnosed with large-sized lesions without loss of myoepithelial cell layer. Patients diagnosed with small-sized lesions without loss of myoepithelial cell layer and who are young in age are to be followed up without the need for lesion excision. The lesions should be adequately sampled.