Psoriatic arthritis is associated with bone loss of the metacarpals

• Published in: Arthritis research & therapy Vol. 18; no. 1; p. 248
• Main Authors: Pfeil, Alexander, Krojniak, Laura, Renz, Diane M, Reinhardt, Lisa, Franz, Marcus, Oelzner, Peter, Wolf, Gunter, Böttcher, Joachim
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25-10-2016; BioMed Central
• Subjects: Adult; Aged; Arthritis; Arthritis, Psoriatic - diagnostic imaging; Arthritis, Psoriatic - pathology; Bones; Density; Female; Health aspects; Humans; Male; Measurement; Metacarpal Bones - diagnostic imaging; Metacarpal Bones - pathology; Metacarpus; Middle Aged; Physiological aspects; Psoriatic arthritis; Radiographic Image Enhancement - methods; BoneXpert; Digital X-ray radiogrammetry; Periarticular demineralisation; Bone mineral density; Cortical bone loss; Psoriatic arthritis
• ISSN: 1478-6362; 1478-6354; 1478-6362
• DOI: 10.1186/s13075-016-1145-4

BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in patients with psoriatic arthritis (PsA) and compare these findings with other radiological scoring methods.
The study includes 104 patients with verified PsA. The BX method was used to measure the Metacarpal Index (MCI) at the metacarpal bones (II-IV). Additionally, the T-score of the MCI (T-score
) was calculated. Radiographic severity was determined by the Psoriatic Arthritis Ratingen Score (Proliferation Score and Destruction Score) as published by Wassenberg et al. and the Psoriatic Arthritis modified van der Heijde Sharp Score (Joint Space Narrowing Score and Erosion Score).
For the total PsA study cohort, the T-score
was significantly reduced by -1.289 ± 1.313 SD. The MCI negatively correlated with the Proliferation Score (r = -0.732; p < 0.001) and the Destruction Score (r = -0.771; p < 0.001) of the Psoriatic Arthritis Ratingen Score. Lower coefficients of correlations were observed for the Psoriatic Arthritis modified van der Heijde Sharp Score. In this context, a severity-dependent and PsA-related periarticular demineralisation as measured by the MCI was quantified. The strongest reduction of -30.8 % (p < 0.01) was observed for the MCI in the Destruction Score.
The BX MCI score showed periarticular demineralisation and severity-dependent bone loss in patients with PsA. The measurements of the BX technique were able to sensitively differentiate between the different stages of disease manifestation affecting bone integrity and thereby seem to achieve the potential to be a surrogate marker of radiographic progression in PsA.