Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Polygonum capitatum Extract

Buch.-Ham. ex D. Don is traditionally used by Hmong for the treatment of urinary tract infections and pyelonephritis. Information regarding the pharmacokinetic behavior of the extract in the condition of pyelonephritis is lacking. In the present study, we aimed to compare the pharmacokinetic propert...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 24; no. 21; p. 3873
Main Authors:	Huang, Yong, Zhou, Zuying, Yang, Wu, Gong, Zipeng, Li, Yueting, Chen, Siying, Wang, Yonglin, Wang, Aimin, Lan, Yanyu, Liu, Ting, Zheng, Lin
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27-10-2019 MDPI
Subjects:	Acids Animals Aquatic plants Blood Chinese medicine Constituents Disease Drug metabolism Drugs, Chinese Herbal - therapeutic use Enzymes Female Gallic acid Gallic Acid - pharmacokinetics Hydroxybenzoates - pharmacokinetics Inflammation Liquid chromatography Mass spectrometry Mass spectroscopy Medical research Metabolism Metabolites Oral administration Parameter estimation Pharmacokinetics Pharmacology Physiology Plant Extracts - therapeutic use Plasma Polygonum - chemistry Polygonum capitatum polygonum capitatum extract Protocatechuic acid Pyelonephritis Pyelonephritis - drug therapy Pyelonephritis - metabolism Quercetin - analogs & derivatives Quercetin - pharmacokinetics quercitrin Rats Rats, Sprague-Dawley uplc-ms/ms Urinary tract Urinary tract diseases Urinary tract infections Urogenital system China pyelonephritis Polygonum capitatum extract quercitrin pharmacokinetics UPLC-MS/MS gallic acid protocatechuic acid
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