Characterization of a Catalase-Negative Methicillin-Resistant Staphylococcus aureus Strain

We describe an unusual clinical strain of catalase-negative methicillin-resistant Staphylococcus aureus sensu stricto. Sequence analysis of its catalase gene showed 99.60% identities to the catalase genes of the reference strains. A 5-base deletion, however, led to a shift of the nucleotide reading...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of Clinical Microbiology Vol. 45; no. 8; pp. 2684 - 2685
Main Authors:	Grüner, B.M, Han, S.-R, Meyer, H.-G, Wulf, U, Bhakdi, S, Siegel, E.K
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-08-2007
Subjects:	Aged Bacteriology Biological and medical sciences Catalase - genetics Catalase - metabolism DNA, Bacterial - chemistry DNA, Bacterial - genetics Fundamental and applied biological sciences. Psychology Humans Male Methicillin Resistance Microbiology Miscellaneous Molecular Sequence Data Sequence Analysis, DNA Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Staphylococcus aureus - isolation & purification Peroxidases Catalase Enzyme Bacteria Micrococcales Micrococcaceae Oxidoreductases Staphylococcus aureus
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We describe an unusual clinical strain of catalase-negative methicillin-resistant Staphylococcus aureus sensu stricto. Sequence analysis of its catalase gene showed 99.60% identities to the catalase genes of the reference strains. A 5-base deletion, however, led to a shift of the nucleotide reading frame and a loss of the enzymatic activity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3 B. M. Grüner and S.-R. Han contributed equally to the paper. Corresponding author. Mailing address: Institute of Medical Microbiology, Johannes Gutenberg University, Hochhaus am Augustusplatz, D-55101 Mainz, Germany. Phone: (49) 6131 3937341. Fax: (49) 6131 3932359. E-mail: srhan@uni-mainz.de
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.02457-06