Acute elevation of lipids does not alter exercise hemodynamics in healthy men: A randomized controlled study

• Published in: Atherosclerosis Vol. 226; no. 1; pp. 234 - 237
• Main Authors: Sharman, James E, Holland, David J, Leano, Rodel, Kostner, Karam M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01-01-2013; Elsevier
• Subjects: Aorta; atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; blood pressure; blood serum; cardiac output; Cardiology. Vascular system; Cardiovascular; Cardiovascular system; Cholesterol; Cross-Over Studies; Double-Blind Method; Emulsions - administration & dosage; exercise; Exercise - physiology; Fat Emulsions, Intravenous - administration & dosage; free fatty acids; Hemodynamics; Humans; hyperlipidemia; Hypertension; Infusions, Intravenous; intravenous injection; long term effects; Male; males; Medical sciences; men; Middle Aged; mortality; Pharmacology. Drug treatments; Phospholipids - administration & dosage; Phospholipids - blood; Physical activity; Soybean Oil - administration & dosage; Soybean Oil - blood; triacylglycerols; Vasodilator agents. Cerebral vasodilators; very low density lipoprotein; Hypertension; Aorta; Hemodynamics; Physical activity; Cholesterol; Physical exercise; Human; Lipids; Cardiovascular disease; Artery; Vascular disease; Blood vessel; Atherosclerosis; Circulatory system
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2012.10.047

Abstract Objective Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but whether acute-hyperlipidemia effects exercise BP has never been tested, and was the aim of this study. Methods Intravenous infusion of saline (control) and Intralipid were administered over 60 min in 15 healthy men by double-blind, randomized, cross-over design. Brachial and central BP (including, pulse pressure, augmentation pressure and augmentation index), cardiac output and systemic vascular resistance were recorded at rest and during exercise. Results Compared with control, Intralipid caused significant increases in serum triglycerides, very low density lipoproteins and free fatty acids ( p  < 0.001 for all). However, there was no significant difference for any exercise hemodynamic variable ( p  > 0.05 for all). Conclusion Acute-hyperlipidemia does not significantly change exercise hemodynamics in healthy males. Therefore, the association between raised lipids and increased exercise BP is likely due to the chronic effects of hyperlipidemia.