Secondary Metabolites and Their Cytotoxic Activity of Artemisia nitrosa Weber. and Artemisia marschalliana Spreng

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 22; p. 8074
• Main Authors: Kazymbetova, Aizhan, Amangeldi, Magzhan, Nurlybekova, Aliya, Amzeyeva, Ulpan, Baktybala, Kunbike, Tang, Chun-Ping, Ke, Chang-Qiang, Yao, Sheng, Ye, Yang, Jenis, Janar
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21-11-2022; MDPI
• Subjects: Antineoplastic Agents; Artemisia - chemistry; Artemisia marschalliana; Artemisia nitrosa; Biological activity; Caffeic acid; Cancer; Cell lines; Chromatography; coumarin; Cytotoxicity; Diketones; Flavones; flavonoid; Flowers & plants; Herbal medicine; Lipopolysaccharides; Malaria; Metabolites; Naphthalene; NMR; Nuclear magnetic resonance; phenolic compound; Phytochemicals - pharmacology; Plant Extracts - chemistry; Secondary metabolites; Sensors; sesquiterpene lactone; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Sesquiterpenoids; Two dimensional analysis; Kazakhstan; China; Germany; Siberia; Russia; Artemisia marschalliana; coumarin; A-549; phenolic compound; Artemisia nitrosa; HL-60; flavonoid; sesquiterpene lactone; cytotoxicity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27228074

As a promising source of biologically active substances, the
species from Kazakhstan have not been investigated efficiently. Considering the rich history, medicinal values, and availability of the
plants, systematic investigations of two
species growing in the East Kazakhstan region were conducted. In this study, one new germacrane-type sesquiterpene lactone (
), together with 10 known sesquiterpenes and its dimer, were characterized from
Weber. Additionally, one new chromene derivative (
') with another 12 known compounds, including coumarins, sesquiterpene diketones, phenyl propanoids, polyacetylenics, dihydroxycinnamic acid derivatives, fatty acids, naphthalene derivatives, flavones, and caffeic acid derivatives were isolated from
Spreng. All compounds were isolated and identified for the first time from these two
species. The structures of new compounds (
,
') were established by using UV, TOFMS, LC-MS, 1D and 2D NMR spectroscopic analyses. The cytotoxicity of all isolated compounds was evaluated. As a result, all compounds did not show significant inhibition against HL-60 and A-549 cell lines. The sesquiterpenoids isolated from
were tested for their inhibitory activity against the LPS-induced NO release from the RAW624.7 cells, and neither of them exhibited significant activity.