Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 11; p. 3559
• Main Authors: Henao-Rojas, Juan Camilo, Osorio, Edison, Isaza, Stephanie, Madronero-Solarte, Inés Amelia, Sierra, Karina, Zapata-Vahos, Isabel Cristina, Betancur-Pérez, Jhon Fredy, Arboleda-Valencia, Jorge W, Gallego, Adriana M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31-05-2022; MDPI
• Subjects: Acids; Annotations; antimicrobial activity; Antimicrobial agents; antioxidant activity; Antioxidants; Bacteria; Biological activity; Bioprospecting; bioprospection; Causality; commercial materials; Discriminant analysis; Drug resistance; Functional foods & nutraceuticals; Gram-positive bacteria; High-performance liquid chromatography; Liquid chromatography; Mentha spicata; Metabolism; Metabolites; Metabolomics; Methicillin; Origins; Rosmarinic acid; spearmint; untargeted metabolomics; Variables; Colombia; Mexico; Egypt; commercial materials; untargeted metabolomics; bioprospection; antimicrobial activity; antioxidant activity; spearmint
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27113559

Spearmint (
L.) has been widely studied for its diversity of compounds for product generation. However, studies describing the chemical and biological characteristics of commercial spearmint materials from different origins are scarce. For this reason, this research aimed to bioprospecting spearmint from three origins: Colombia (Col), Mexico (Mex), and Egypt (Eg). We performed a biological activity analysis, such as FRAP, DPPH, and ABTS, inhibition potential of
,
,
,
,
,
Methicillin-Resistant, and
Furthermore, we performed chemical assays, such as total polyphenol and rosmarinic acid, and untargeted metabolomics via HPLC-MS/MS. Finally, we developed a causality analysis to integrate biological activities with chemical analyses. We found significant differences between the samples for the total polyphenol and rosmarinic acid contents, FRAP, and inhibition analyses for Methicillin-Resistant
and
. Also, clear metabolic differentiation was observed among the three commercial materials evaluated. These results allow us to propose data-driven uses for the three spearmint materials available in current markets.