Two-Year Clinical Outcome After Abciximab-Coated Stent Implantation in Patients With Coronary Artery Disease

• Published in: Circulation Journal Vol. 74; no. 3; pp. 442 - 448
• Main Authors: Kim, Sung Soo, Hong, Young Joon, Jeong, Myung Ho, Kim, Weon, Kim, Hyun-Kuk, Ko, Jum Suk, Lee, Min Goo, Sim, Doo Sun, Park, Keun Ho, Yoon, Nam Sik, Yoon, Hyun Ju, Kim, Kye Hun, Park, Hyung Wook, Kim, Ju Han, Ahn, Youngkeun, Cho, Jeong Gwan, Park, Jong Chun, Song, Sun-Jung, Cho, Dong Lyun, Kang, Jung Chaee
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 01-03-2010
• Subjects: Abciximab; Aged; Angioplasty, Balloon, Coronary - mortality; Antibodies, Monoclonal - therapeutic use; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - mortality; Coronary Artery Disease - therapy; Coronary Restenosis - mortality; Coronary Restenosis - prevention & control; Coronary Thrombosis - mortality; Coronary Thrombosis - prevention & control; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - prevention & control; Disease-Free Survival; Drug-Eluting Stents - statistics & numerical data; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments - therapeutic use; Incidence; Kaplan-Meier Estimate; Male; Metals; Middle Aged; Platelet Aggregation Inhibitors - therapeutic use; Prospective Studies; Restenosis; Stents; Thrombosis; Treatment Outcome; Ultrasonography, Interventional
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-09-0674

Background: Despite abciximab-coated stents having an inhibitory effect on coronary artery restenosis, the medium-term clinical outcome is unknown. Methods and Results: This prospective, randomized study compared the effects of the abciximab-coated stent, which was implanted in 95 patients, with those of control bare metal stents (BMS) implanted in 93 patients for de novo coronary lesions. Stent implantation was performed without any complications associated with the procedure. The 6-month intravascular ultrasound analysis showed that the area of neointimal hyperplasia was significantly smaller in the abciximab-coated stent group compared with the control stent group (+2.0±1.6 mm2 vs +3.4±1.7 mm2, P=0.001). However, at 2-year clinical follow up, there were no statistically significant differences in the incidences of total major adverse cardiac events (16% vs 24%, P=0.19) and cardiac death (0% vs 1.1%, P=0.3), target vessel revascularization (16% vs 21%, P=0.4) or non-fatal myocardial infarction (0% vs 2.3%, P=0.16) in the abciximab-coated stent group compared with the control stent group. Conclusions: Although abciximab-coated stents are safe and inhibit neointimal hyperplasia, they have no superiority over BMS in 2-year clinical outcome. (Circ J 2010; 74: 442 - 448)