Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

• Published in: Journal of neuroimmunology Vol. 276; no. 1; pp. 80 - 88
• Main Authors: Jafarzadeh, A, Mohammadi-Kordkhayli, M, Ahangar-Parvin, R, Azizi, V, Khoramdel-Azad, H, Shamsizadeh, A, Ayoobi, A, Nemati, M, Hassan, Z.M, Moazeni, S.M, Khaksari, M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-11-2014
• Subjects: Allergy and Immunology; Animals; Body Weight - drug effects; Central Nervous System - drug effects; Central Nervous System - metabolism; Chemotaxis, Leukocyte - drug effects; Clinical symptoms; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental - blood; Encephalomyelitis, Autoimmune, Experimental - chemically induced; Encephalomyelitis, Autoimmune, Experimental - drug therapy; Experimental autoimmune encephalomyelitis; Female; Freund's Adjuvant - toxicity; Ginger; IL-27; IL-33; Interferon-gamma - blood; Interleukin-27 - genetics; Interleukin-27 - metabolism; Interleukin-33; Interleukin-7 - blood; Interleukins - genetics; Interleukins - metabolism; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein - toxicity; Neurology; Peptide Fragments - toxicity; Phytotherapy; Plant Extracts - therapeutic use; Time Factors; Zingiber officinale - chemistry; Experimental autoimmune encephalomyelitis; IL-27; Clinical symptoms; Ginger; IL-33
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2014.08.614

Abstract The immunomodulatory effects of the IL-27 and IL-33 and the anti-inflammatory effects of ginger have been reported in some studies. The aim was to evaluate the effects of the ginger extract on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). In PBS-treated EAE mice the expression of IL-27 P28 was significantly lower whereas the expression of IL-33 was significantly higher than unimmunized control mice. In 200 and 300 mg/kg ginger-treated EAE groups the expression of IL-27 P28 and IL-27 EBI3 was significantly higher whereas the expression of IL-33 was significantly lower than PBS-treated EAE mice. The EAE clinical symptoms and the pathological scores were significantly lower in ginger-treated EAE groups. These results showed that the ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease.