One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 4; p. 937
• Main Authors: Ignatovich, Zhanna, Novik, Khristina, Abakshonok, Anna, Koroleva, Elena, Beklemisheva, Anna, Panina, Larisa, Kaniukov, Egor, Anisovich, Marina, Shumskaya, Alena
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10-02-2021; MDPI
• Subjects: 2-arylaminopyrimidine derivatives; Apoptosis; Bioavailability; Biocompatibility; Biological activity; Biomedical materials; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - pathology; Cell culture; Chemical bonds; Cytotoxicity; Drug delivery; Drug delivery systems; Drugs; Enzymes; Ferric Compounds - chemistry; Ferric oxide; Fourier transforms; Hep G2 Cells; Hepatocytes; Humans; Hydroxyapatite; Hyperthermia; Iron oxides; Liver Neoplasms - drug therapy; Liver Neoplasms - pathology; magnetic nanoparticles; Magnetic properties; Magnetite; Magnetite Nanoparticles - administration & dosage; Magnetite Nanoparticles - chemistry; Molecular weight; Nanocomposites; Nanocomposites - chemistry; Nanoparticles; Particle size; Physical properties; Pyrimidines - chemistry; targeted drug delivery; Tissue engineering; hydroxyapatite; magnetite; targeted drug delivery; 2-arylaminopyrimidine derivatives; magnetic nanoparticles
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26040937

Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe
O
and γ-Fe
O
). The possibility of expanding the proposed technique for the synthesis of magnetic composite with embedded biologically active substance (BAS) of the 2-arylaminopyrimidine group was shown. The composition, morphology, structural features, and magnetic characteristics of the nanocomposites synthesized with and without BAS were studied. The introduction of BAS into the composite synthesis resulted in minor changes in the structural and physical properties. The specificity of the chemical bonds between BAS and the hydroxyapatite-magnetite core was revealed. The kinetics of the BAS release in a solution simulating the stomach environment was studied. The cytotoxicity of (HAP)FexOy and (HAP)FexOy + BAS composites was studied in vitro using the primary culture of human liver carcinoma cells HepG2. The synthesized magnetic composites with BAS have a high potential for use in the biomedical field, for example, as carriers for magnetically controlled drug delivery and materials for bone tissue engineering.