Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 24; p. 7453
• Main Authors: Trinidad-Calderón, Plinio A, Varela-Chinchilla, Carlos Daniel, García-Lara, Silverio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09-12-2021; MDPI
• Subjects: Amino acids; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Apoptosis; Bioavailability; Biocompatibility; Biological activity; Cancer; Cancer therapies; cell; Cell death; Cell Death - drug effects; Chemotherapy; Cholesterol; Cytotoxicity; death; Drug development; Humans; Lipids; mechanism; Membranes; Molecular modelling; Mortality; Neoplasms - drug therapy; Neoplasms - metabolism; peptide; Peptides; Peptides - chemistry; Peptides - therapeutic use; Review; therapeutics; Tumors; peptide; therapeutics; membrane; death; apoptosis; cancer; model; cell; mechanism
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26247453

Nowadays, cancer has become the second highest leading cause of death, and it is expected to continue to affect the population in forthcoming years. Additionally, treatment options will become less accessible to the public as cases continue to grow and disease mechanisms expand. Hence, specific candidates with confirmed anticancer effects are required to develop new drugs. Among the novel therapeutic options, proteins are considered a relevant source, given that they have bioactive peptides encrypted within their sequences. These bioactive peptides, which are molecules consisting of 2-50 amino acids, have specific activities when administered, producing anticancer effects. Current databases report the effects of peptides. However, uncertainty is found when their molecular mechanisms are investigated. Furthermore, analyses addressing their interaction networks or their directly implicated mechanisms are needed to elucidate their effects on cancer cells entirely. Therefore, relevant peptides considered as candidates for cancer therapeutics with specific sequences and known anticancer mechanisms were accurately reviewed. Likewise, those features which turn certain peptides into candidates and the mechanisms by which peptides mediate tumor cell death were highlighted. This information will make robust the knowledge of these candidate peptides with recognized mechanisms and enhance their non-toxic capacity in relation to healthy cells and further avoid cell resistance.