The Effect of Various Hormones on the Humoral Immune Response of Murine Lymphocytes in Vitro

Human chorionic gonadotropin (HCG) and steroid hormones were tested for their direct effects on murine lymphocyte humoral response to sheep RBCs using an in vitro culture system. A significant increase in plaque forming cells (PFC) was induced by the addition of HCG at a dose of either 50 i.u. or 50...

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Bibliographic Details
Published in:	The Tohoku Journal of Experimental Medicine Vol. 126; no. 3; pp. 235 - 238
Main Authors:	OKAMURA, KUNIHIRO, KURAMOTO, MASAKI, HAMAZAKI, YOHICHI, SUZUKI, MASAKUNI
Format:	Journal Article
Language:	English
Published:	Japan Tohoku University Medical Press 1978
Subjects:	Animals Chorionic Gonadotropin - pharmacology Estrogens - pharmacology hormones humoral immune response In Vitro Techniques Lymphocytes - immunology Mice Progesterone - pharmacology
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Summary:	Human chorionic gonadotropin (HCG) and steroid hormones were tested for their direct effects on murine lymphocyte humoral response to sheep RBCs using an in vitro culture system. A significant increase in plaque forming cells (PFC) was induced by the addition of HCG at a dose of either 50 i.u. or 500 i.u. However, no increase was observed by the addition of steroid hormones. HCG may contribute to the success of fetal allografts by increasing the number of blocking antibodies in the early stages of pregnancy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0040-8727 1349-3329
DOI:	10.1620/tjem.126.235