Myelin peptides in multiple sclerosis

• Published in: Autoimmunity reviews Vol. 8; no. 8; pp. 650 - 653
• Main Authors: Grau-López, L, Raïch, D, Ramo-Tello, C, Naranjo-Gómez, M, Dàvalos, A, Pujol-Borrell, R, Borràs, F.E, Martínez-Cáceres, E
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-07-2009
• Subjects: Allergy and Immunology; alpha-Crystallin B Chain - immunology; Animals; Antigens - immunology; CD4-Positive T-Lymphocytes - immunology; Cell proliferation; Cell therapy; Encephalomyelitis, Autoimmune, Experimental - immunology; Humans; Multiple sclerosis; Multiple Sclerosis - immunology; Multiple Sclerosis - therapy; Myelin peptides; Myelin Sheath - immunology; Myelin-Associated Glycoprotein - immunology; Peptides - immunology; S100 Proteins - immunology; T-cell reactivity; Transaldolase - immunology; Cell proliferation; Multiple sclerosis; Cell therapy; T-cell reactivity; Myelin peptides
• ISSN: 1568-9972; 1568-9972; 1873-0183
• DOI: 10.1016/j.autrev.2009.02.013

Abstract The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized by both pathogenic T cells and autoantibodies. Here, we review the most relevant studies focused in the identification of peptides in multiple sclerosis (MS) and the distinct T cell reactivity induced in patients compared to controls. Only a few studies reported significant differences in terms of T cell reactivity to them. The current knowledge on this issue, and the diagnostic and therapeutic possibilities opened by the identification of pathogenic MS epitopes are discussed in this paper.