1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.

Saved in:

Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 14; no. 12; pp. 5247 - 5280
Main Authors:	Shin, Jai Moo, Sachs, George, Cho, Young-moon, Garst, Michael
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 15-12-2009 Molecular Diversity Preservation International
Subjects:	Acids Benzimidazoles - chemistry Benzimidazoles - pharmacology Blood Drug dosages gastric acid secretion Humans Hydrolysis Magnetic Resonance Spectroscopy prodrug Prodrugs - chemistry Prodrugs - pharmacology proton pump inhibitor Proton Pump Inhibitors - chemistry Proton Pump Inhibitors - pharmacology Protons Los Angeles California United States > US California
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules14125247