Relationship among muscle strength, muscle endurance, and skeletal muscle oxygenation dynamics during ramp incremental cycle exercise

• Published in: Scientific reports Vol. 14; no. 1; p. 11676
• Main Authors: Nemoto, Shinji, Nakabo, Tohru, Tashiro, Naonori, Kishino, Asami, Yoshikawa, Akira, Nakamura, Daisuke, Geshi, Eiichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22-05-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/1537; 692/308; 692/700; Adult; Cardiopulmonary exercise testing; Endurance; Exercise - physiology; Exercise Test; Humanities and Social Sciences; Humans; Infrared spectroscopy; Leg; Male; multidisciplinary; Muscle endurance; Muscle oxygen saturation; Muscle strength; Muscle Strength - physiology; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Muscles; Musculoskeletal system; Near-infrared spectroscopy; Oxygen - metabolism; Oxygen Consumption - physiology; Oxygen Saturation - physiology; Oxygen uptake; Oxygenation; Physical Endurance - physiology; Science; Science (multidisciplinary); Skeletal muscle; Skeletal muscle oxygenation; Spectroscopy, Near-Infrared; Young Adult; Muscle endurance; Skeletal muscle oxygenation; Muscle oxygen saturation; Muscle strength; Cardiopulmonary exercise testing; Near-infrared spectroscopy
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-61529-x

Peak oxygen uptake (VO
2
), evaluated as exercise tolerance, is a strong predictor of life prognosis regardless of health condition. Several previous studies have reported that peak VO
2
is higher in those with a greater decrease in muscle oxygen saturation (SmO
2
) in the active muscles during incremental exercise. However, the skeletal muscle characteristics of individuals exhibiting a greater decrease in SmO
2
during active muscle engagement in incremental exercise remain unclear. This study aimed to clarify the relationship among muscle strength, muscle endurance, and skeletal muscle oxygenation dynamics in active leg muscles during incremental exercise. Twenty-four healthy young men were included and categorized into the non-moderate-to-high muscular strength and endurance group (those with low leg muscle strength, endurance, or both; n = 11) and the moderate-to-high muscular strength and endurance group (those with both moderate-to-high leg muscle strength and endurance; n = 13). All participants underwent cardiopulmonary exercise testing combined with near-infrared spectroscopy to assess whole-body peak VO
2
and the change in SmO
2
at the lateral vastus lateralis from rest to each exercise stage as skeletal muscle oxygenation dynamics. A linear mixed-effects model, with the change in SmO
2
from rest to each stage as the dependent variable, individual participants as random effects, and group and exercise load as fixed effects, revealed significant main effects for both group (
P
 = 0.001) and exercise load (
P
 < 0.001) as well as a significant interaction between the two factors (
P
 < 0.001). Furthermore, multiple-comparison test results showed that the change in SmO
2
from rest to 40%–100% peak VO
2
was significantly higher in the moderate-to-high muscular strength and endurance group than in the non-moderate-to-high muscular strength and endurance group. Maintaining both muscle strength and endurance at moderate or higher levels contributes to high skeletal muscle oxygenation dynamics (i.e., greater decrease in SmO
2
) during moderate- or high-intensity exercise.