Pharmacological Correction of Alcohol Motivation Depends on the Phenotype of the Response to Emotional Stress

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 4; pp. 508 - 512
• Main Authors: Kolik, L. G., Gudasheva, T. A., Martyanov, V. A., Seredenin, S. B.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-08-2016; Springer; Springer Nature B.V
• Subjects: Alcoholism - drug therapy; Alcoholism - psychology; Analysis; Animals; Anti-Anxiety Agents - therapeutic use; Antianxiety agents; Behavior, Animal; Biomedical and Life Sciences; Biomedicine; Cell Biology; Choice Behavior - drug effects; Dipeptides - therapeutic use; Ethanol; Genetic aspects; Internal Medicine; Laboratory Medicine; Male; Motivation - drug effects; Neuropeptides; Pathology; Psychological aspects; Rats; Stress (Psychology); Stress, Psychological - drug therapy; Tryptophan; MR and MNRA rats; anxiolytic; GB-115; ethanol consumption
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3449-4

The specific features of alcohol behavior were studied in MR and MNRA rats that exhibit an opposite reaction to emotional stress. We evaluated the effect of a dipeptide anxiolytic GB-115 (N-phenyl-hexanoyl-glycyl-L-tryptophan amide, neuropeptide cholecystokinin-4 analogue with antagonistic activity) on alcohol motivation in rats, which was formed over 12 months. High-emotionality MR rats were more sensitive to the anxiolytic effect of ethanol in the conflict situation test than low-emotionality MNRA rats. MNRA rats consumed a greater amount of ethanol under a free-choice condition with 15% ethanol solution and water (as in comparison with MR rats). However, the behavior of MR rats was transformed due to a significant increase in alcohol motivation from the 5th month of long-term free access to ethanol. An anxiolytic GB-115 (0.025 mg/kg intraperitoneally for 14 days) with selective activity in high-emotionality rats was shown to reduce significantly the average daily consumption and alcohol-deprivation effect in MR rats, but did not modulate ethanol addiction in MNRA rats.