Comparison of cardiometabolic risk factors between obese and non-obese patients with nonalcoholic fatty liver disease

• Published in: Scientific reports Vol. 13; no. 1; pp. 14531 - 7
• Main Authors: Yari, Zahra, Fotros, Danial, Hekmatdoost, Azita
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04-09-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4020; 692/699; Adipose tissue; Blood levels; Body mass index; Body measurements; Body weight; Cardiometabolic Risk Factors; Cross-Sectional Studies; Fatty liver; Health risks; Humanities and Social Sciences; Humans; Liver diseases; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - epidemiology; multidisciplinary; Non-alcoholic Fatty Liver Disease - complications; Obesity - complications; Overweight; Regression analysis; Risk factors; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-41893-w

Nonalcoholic fatty liver disease (NAFLD) is closely associated with cardiometabolic abnormalities. This association could be partly influenced by weight, but not entirely. This study aimed to compare the cardiometabolic risk factors between obese and non-obese NAFLD patients, and explored the relationship between adiposity and severity of fatty liver. This cross-sectional study included 452 patients with Fibroscan-proven NAFLD. Anthropometric measurements, metabolic components and hepatic histological features were evaluated. The risk of metabolic syndrome in each body mass index (BMI) category was analyzed using logistic regression. The prevalence of metabolic syndrome was 10.2%, 27.7%, and 62.1% in normal-weight, overweight and obese participants. Regression analysis showed that the risk of metabolic syndrome in overweight and obese NAFLD patients was 3.74 and 4.85 times higher than in patients with normal weight, respectively. Waist circumference (β = 0.770, P < 0.001) and serum concentration of fasting blood glucose (β = 0.193, P = 0.002) and triglyceride (β = 0.432, P < 0.001) were the determinants of metabolic syndrome occurrence in NAFLD patients. Metabolic abnormalities were similar in obese and non-obese NAFLD patients, although, the increase in BMI was associated with an increased risk of metabolic syndrome in patients.