Antihypertensive effects of the combined extract of Sorghum bicolor, Vigna angularis, and Eleusine coracana in spontaneously hypertensive rats

• Published in: Scientific reports Vol. 14; no. 1; p. 803
• Main Authors: Jeong, Eunwoo, Yun, Damin, Baek, Youjin, Kim, Hyun-Joo, Lee, Hyeon Gyu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08-01-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/449; 692/163; 692/699; Alanine transaminase; Animals; Antihypertensive Agents - pharmacology; Antihypertensives; Aspartate aminotransferase; Beans; Blood pressure; Body composition; Body fat; Body weight; Cardiovascular disease; Cardiovascular diseases; Crop diseases; Crop science; Dietary Supplements; Efficiency; Eleusine; Eleusine coracana; Experiments; Fibrosis; Food; Food intake; Heart; Heart failure; Hepatotoxicity; Humanities and Social Sciences; Hypertension; Laboratory animals; multidisciplinary; Nutrition research; Plant extracts; Plant Extracts - pharmacology; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Science; Science (multidisciplinary); Software; Sorghum; Sorghum bicolor; Vigna; Vigna angularis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-51364-5

This study investigated the antihypertensive effects of the combined extract of sorghum, adzuki bean, and finger millet (SAFE) on spontaneously hypertensive rats. The rats were divided into four groups (
n
 = 8): WKY, SHR, SAFE (500 mg/kg SAFE), and CAP (50 mg/kg captopril). SAFE significantly decreased the lean-to-fat mass ratio with no notable changes in body weight, food intake, or food efficiency ratio, and it effectively lowered both systolic and diastolic blood pressures, comparable to CAP. Moreover, it significantly reduced the cardiac mass index and alleviated cardiac fibrosis. SAFE did not induce hepatotoxicity, as indicated by the maintenance of aspartate aminotransferase and alanine aminotransferase levels in the normal range, confirming its safety. Taken together, these findings suggested that SAFE can be used as a dietary supplement for blood pressure regulation and cardiovascular disease prevention.