Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women

• Published in: BMC musculoskeletal disorders Vol. 24; no. 1; pp. 1 - 659
• Main Authors: Xu, PengChao, Ge, JiRong, Jiang, Hong, Lin, YuJuan, Ye, YunJin, Huang, XiaoBin, He, YanYan, Xue, LiPeng
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 18-08-2023; BioMed Central; BMC
• Subjects: Arthritis; Body mass index; Cardiovascular disease; Case control study; Chinese postmenopausal women; Correlation analysis; Development and progression; Evaluation; Fractures; Gastric cancer; Gastrointestinal diseases; Gastrointestinal surgery; Health aspects; Hypertension; Inflammatory bowel disease; Inflammatory bowel diseases; Medical records; Metabolism; Musculoskeletal diseases; Older people; Osteoporosis; Osteoporotic fracture; Post-menopause; Postmenopausal women; Quality of life; Questionnaires; Risk factors; Statistical analysis; Thyroid gland; Vertebrae; Womens health; China
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-023-06765-4

Backgroud The influencing factors of osteoporosis are complex, the incidence of osteoporosis is higher in middle-aged and elderly women, and osteoporotic fractures (OF) can seriously affect quality of life. Currently, the correlation analysis between gastrointestinal diseases and OF focuses more on diseases such as gastric cancer and inflammatory bowel disease (IBD). This study analyzed the risk factors for osteoporosis and osteoporotic fractures in 1567 postmenopausal women in Fuzhou, China. The purpose is to explore the potential influence of gastrointestinal diseases on the occurrence of OF. Methods According to inclusion and exclusion criteria, a total of 1567 subjects were included in the analysis of OP risk factors, including 647 in the OP group and 920 in the NOP group. A total of 616 subjects were included in the analysis of correlation between OF and gastrointestinal diseases, including 132 in OF group and 484 in NF group. Statistical analysis shows that age (OR = 1.062, 95% CI = 1.045-1.080), height (OR = 0.089, 95% CI = 0.009-0.857), weight (OR = 0.981,95% CI = 0.967-0.995) and nature of work (P = 0.010) are the main risk factors for osteoporosis in postmenopausal women in southeast China, and gastrointestinal diseases (OR = 1.583, 95% CI = 1.070-2.343) and height (OR = 0.003, 95% CI = 0.000-0.104) are the main risk factors of OF. Conclusions The main factors affecting the occurrence of OP in postmenopausal women in southeast China are individual characteristic. Gastrointestinal diseases that do not directly affect BMD increase the risk of OF in osteoporotic patients. Keywords: Osteoporosis, Osteoporotic fracture, Gastrointestinal diseases, Case control study, Chinese postmenopausal women