Manifestation of Adaptive Changes during Combined Development of Postinfarction Remodeling of the Heart and Diabetes Mellitus

• Published in: Bulletin of experimental biology and medicine Vol. 150; no. 2; pp. 172 - 174
• Main Authors: Egorova, M. V, Afanas'ev, S. A, Popov, S. V, Karpov, R. S
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01-12-2010; Springer US; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blood Glucose; Body weight; Cell Biology; Cell Respiration - physiology; Development and progression; Dextrose; Diabetes; diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Fatty acids; Glucose; Glucose metabolism; Internal Medicine; Laboratory Medicine; Male; Metabolites; mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Myocardial Infarction - complications; Myocardial Infarction - metabolism; Myocytes, Cardiac - metabolism; Oxidative Phosphorylation; Oxygen Consumption; Pathology; Physiological aspects; postinfarction remodeling; Rats; Rats, Wistar; Respiratory Rate; Triglycerides; Ventricular Remodeling - physiology; postinfarction remodeling; mitochondria; diabetes mellitus
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-1096-8

Oxidative phosphorylation in isolated cardiomyocytes was studied under conditions of postinfarction remodeling and diabetes mellitus. Oxidation-phosphorylation uncoupling in the mitochondria in this disease combination was less pronounced than in each of these diseases alone. Combined development of the diseases was paralleled by less severe hyperglycemia and myocardial hypertrophy and lesser body weight loss. Presumably, combination of coronary occlusion and diabetes mellitus stimulates the adaptive changes in cardiomyocytes as early as at the level of mitochondrial energy metabolism.