Association of type 2 diabetes with family history of diabetes, diabetes biomarkers, mental and physical disorders in a Kenyan setting

• Published in: Scientific reports Vol. 14; no. 1; p. 11037
• Main Authors: Ndetei, David M., Mutiso, Victoria, Musyimi, Christine, Nyamai, Pascalyne, Lloyd, Cathy, Sartorius, Norman
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14-05-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/477; 692/163; 692/499; Adult; Aged; Biomarkers; Demography; Depression; Depression - epidemiology; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Eating disorders; Family relations; Female; Genetics; Humanities and Social Sciences; Humans; Hypertension; Kenya - epidemiology; Kenyan setting; Male; Mental depression; Mental disorders; Mental Disorders - diagnosis; Mental Disorders - epidemiology; Middle Aged; multidisciplinary; Patients; Physical conditions; Quality of life; Regression analysis; Retinopathy; Science; Science (multidisciplinary); Sociodemographics; Type 2 diabetes mellitus; Variance analysis; Well being; Kenya; Depression; Physical conditions; Type 2 diabetes mellitus; Kenyan setting; Family relations
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-61984-6

This study aimed to determine the degree of family relations and associated socio-demographics characteristics, clinical/physical and mental disorders in type 2 diabetes mellitus in a Kenyan diabetes clinic. This study was part of a large multicentre study whose protocol and results had been published. It took place at the outpatient diabetes clinic at a County Teaching and Referral Hospital in South East Kenya involving 182 participants. We used a socio-demographic questionnaire, the Hamilton Depression (HAM-D) and PHQ-9 rating scales for depression, the MINI International Neuropsychiatric Interview (MINI; V5 or V6) for DSM-5 diagnoses, the WHO-5 Well-being scale and Problem Areas in Diabetes Scale (PAID). We extracted from the notes all physical conditions. We enquired about similar conditions in 1st and 2nd degree relatives. Descriptive, Chi-square test, Fisher’s exact test, one way ANOVA, and Multinomial logistic regression analysis were conducted to test achievements of our specific aims. Of the 182 patients who participated in the study, 45.1% (82/182) reported a family history of diabetes. Conditions significantly (
p
 < 0.05) associated with a degree of family history of diabetes were retinopathy, duration of diabetes (years), hypertension, and depressive disorder. On average 11.5% (21/182) scored severe depression (≥ 10) on PHQ-9 and 85.2% (115/182) scored good well-being (≥ 13 points). All DSM-5 psychiatric conditions were found in the 182 patients in varying prevalence regardless of relations. In addition, amongst the 182 patients, the highest prevalence was poor well-being on the WHO quality of life tool. This was followed by post-traumatic disorders (current), suicidality, and psychotic lifetime on DSM-5. The least prevalent on DSM-5 was eating disorders. Some type 2 diabetes mellitus physical disorders and depression have increased incidence in closely related patients. Overall, for all the patients, the prevalence of all DSM-5 diagnoses varied from 0.5 to 9.9%.