Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study

• Published in: Scientific reports Vol. 14; no. 1; p. 296
• Main Authors: Peng, Peng, Wu, Jiawei, Fang, Weihua, Tian, Jiaqing, He, Mincong, Xiao, Fangjun, Lin, Kun, Xu, Xuemeng, He, Wei, Liu, Wengang, Wei, Qiushi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02-01-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/308/174; Adult; Body mass index; Body weight; Cross-Sectional Studies; Humanities and Social Sciences; Humans; multidisciplinary; Muscle, Skeletal; Musculoskeletal system; Nutrition Surveys; Osteoarthritis; Osteoarthritis - complications; Osteoarthritis - epidemiology; Prospective Studies; Regression analysis; Sarcopenia; Sarcopenia - complications; Sarcopenia - diagnosis; Sarcopenia - epidemiology; Science; Science (multidisciplinary); Skeletal muscle; United States > US
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-50528-z

The association between sarcopenia and OA still presents many uncertainties. We aimed to assess whether sarcopenia is associated with occurrence of OA in US adults. We conducted a cross-sectional study consisting of 11,456 participants from National Health and Nutrition Examination Survey 1999–2006. Sarcopenia was defined by a low muscle mass. The skeletal muscle index (SMI) was calculated as the appendicular skeletal muscle mass divided by body mass indexes (BMI) or body weight. OA status was assessed by using self-reported questionnaire. We evaluated the association between sarcopenia and OA using multivariate regression models. In addition, subgroup and interaction analysis were performed. Sarcopenia was associated with OA when it was defined by the BMI-adjusted SMI (OR = 1.23 [95% CI, 1.01, 1.51];
P
 = 0.038) and defined by the weight-adjusted SMI (OR = 1.30 [95% CI, 1.10, 1.55];
P
 = 0.003). Subgroup and interaction analysis found that the strongest positive association mainly exists in smoker (OR = 1.54 [95% CI, 1.21, 1.95], Pint = 0.006), and this association is not significant in other groups. In conclusion, we found that sarcopenia was associated with occurrence of OA. Subgroup analysis revealed that the association between sarcopenia and OA was more pronounced in smoker. Further well-designed prospective cohort studies are needed to assess our results.