Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication)

Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication)

A combination of direct liquid extraction using a small volume of solvent and electrospray ionization allows the rapid measurement of complex chemical components in biological samples and visualization of their distribution in tissue sections. This review describes the development of such techniques...

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Bibliographic Details
Published in:Mass Spectrometry Vol. 10; no. 1; p. A0095
Main Author: Otsuka, Yoichi
Format: Journal Article
Language:English
Published: Tokyo The Mass Spectrometry Society of Japan 2021
Japan Science and Technology Agency
Subjects:
Acceleration
Biological properties
charged droplet
Chemical reactions
derivatization
direct extraction
electrospray ionization
Electrospraying
Ionization
mass spectrometry imaging
Review
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Description
Summary:A combination of direct liquid extraction using a small volume of solvent and electrospray ionization allows the rapid measurement of complex chemical components in biological samples and visualization of their distribution in tissue sections. This review describes the development of such techniques and their application to biological research since the first reports in the early 2000s. An overview of electrospray ionization, ion suppression in samples, and the acceleration of specific chemical reactions in charged droplets is also presented. Potential future applications for visualizing multimolecular environments in biological systems are discussed.
ISSN:2187-137X
2186-5116
DOI:10.5702/massspectrometry.A0095