GLUT‐1 expression and response to chemoradiotherapy in rectal cancer

• Published in: International journal of cancer Vol. 125; no. 12; pp. 2778 - 2782
• Main Authors: Brophy, Sarah, Sheehan, Katherine M., McNamara, Deborah A., Deasy, Joseph, Bouchier‐Hayes, David J., Kay, Elaine W.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15-12-2009; Wiley-Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biomarkers, Tumor - metabolism; chemoradiotherapy; Combined Modality Therapy; Female; Gastroenterology. Liver. Pancreas. Abdomen; Glucose Transporter Type 1 - metabolism; GLUT‐1; Humans; hypoxia; Immunoenzyme Techniques; Male; Medical sciences; Middle Aged; p53; Preoperative Care; Prognosis; rectal cancer; Rectal Neoplasms - drug therapy; Rectal Neoplasms - metabolism; Rectal Neoplasms - radiotherapy; Rectal Neoplasms - therapy; Retrospective Studies; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Outcome; Tumor Suppressor Protein p53 - metabolism; Tumors; Oxygen; Rectal disease; rectal cancer; Malignant tumor; Rectum cancer; Chemoradiotherapy; p53; Cancerology; TP53 Gene; GLUT1 glucose transporter; GLUT-1; Digestive diseases; Intestinal disease; Hypoxia; Anorectal disease; Cancer; Tumor suppressor gene
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.24693

Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do not undergo significant regression. Identification of predictive markers of response to chemoradiotherapy would improve patient selection and may allow response modification by targeting of specific pathways. The aim of this study was to determine whether expression of glucose transporter‐1 (GLUT‐1) and p53 in pretreatment rectal cancer biopsies was predictive of tumor response to chemoradiotherapy. Immunohistochemical staining for GLUT‐1 and p53 was performed on 69 pretreatment biopsies and compared to tumor response in the resected specimen as determined by the tumor regression grade (TRG) scoring system. GLUT‐1 expression was significantly associated with reduced response to chemoradiotherapy and increasing GLUT expression correlated with poorer response (p = 0.02). GLUT‐1 negative tumors had a 70% probability of good response (TRG3/4) compared to a 31% probability of good response in GLUT‐1 positive tumors. GLUT‐1 may be a useful predictive marker of response to chemoradiotherapy in rectal cancer. © 2009 UICC