The cellular geography of Aurora kinases

Aurora is the name given to a family of highly conserved protein kinases with essential roles in many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals have three: Aurora A, B and C. During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton an...

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Bibliographic Details
Published in:	Nature reviews. Molecular cell biology Vol. 4; no. 11; pp. 842 - 854
Main Authors:	Carmena, Mar, Earnshaw, William C
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-11-2003
Subjects:	Animals Aurora Kinases Aurora protein Cell Cycle Proteins Cell division Centrosome - enzymology Chromosomes Chromosomes - enzymology Geography Humans Insects Kinases Meiosis - physiology Neoplasms - enzymology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Proteins Spindle Apparatus - enzymology Xenopus Proteins Yeasts
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Summary:	Aurora is the name given to a family of highly conserved protein kinases with essential roles in many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals have three: Aurora A, B and C. During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore. They also regulate signalling by the spindle-assembly checkpoint pathway and cytokinesis. Perturbation of Aurora kinase expression or function might lead to cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm1245