Association studies for finding cancer-susceptibility genetic variants

Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the searc...

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Bibliographic Details
Published in:	Nature reviews. Cancer Vol. 4; no. 11; pp. 850 - 860
Main Authors:	Ponder, Bruce A. J, Pharoah, Paul D. P, Dunning, Alison M, Easton, Douglas F
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-11-2004
Subjects:	Cancer Cell Transformation, Neoplastic Control Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genetic Variation Genotype Humans Neoplasms - genetics Physiological aspects Research Design Risk factors United Kingdom
Online Access:	Get full text
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Summary:	Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of cancer, and it is likely that many genes with modest effects are yet to be found. Genetic-association studies have been widely used in the search for such genes, but success has been limited so far. Increased knowledge of the function of genes and the architecture of human genetic variation combined with new genotyping technologies herald a new era of gene mapping by association.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc1476