An attenuated bovine herpesvirus 1 marker vaccine induces a better protection than two inactivated marker vaccines

• Published in: Veterinary microbiology Vol. 52; no. 3; pp. 223 - 234
• Main Authors: Bosch, J.C., Kaashoek, M.J., Kroese, A.H., van Oirschot, J.T.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-10-1996; Elsevier Science
• Subjects: Animals; Antibodies, Viral - biosynthesis; Biological and medical sciences; Body Temperature; BOVIN; BOVINE HERPESVIRUS; Bovine herpesvirus 1; CATTLE; Cattle Diseases - prevention & control; Female; Fundamental and applied biological sciences. Psychology; GANADO BOVINO; Herpesviridae Infections - prevention & control; Herpesviridae Infections - veterinary; Herpesvirus 1, Bovine - immunology; HERPESVIRUS BOVIN; HERPESVIRUS BOVINO; ID Lelystad, Institute for Animal Science and Health; ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid; Infectious Bovine Rhinotracheitis - prevention & control; Microbiology; Nasal Mucosa - pathology; Random Allocation; VACCIN; VACCINATION; Vaccination - veterinary; VACCINES; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Attenuated - immunology; Vaccines, Inactivated - immunology; VACUNA; VACUNACION; Viral Vaccines - immunology; Virology; Virus Shedding; Bovine herpesvirus 1; Vaccination; Immunoprotection; Bovine; Herpesviridae; Alphaherpesvirinae; Vaccine; Virus; Vertebrata; Mammalia; Immunogenicity; Artiodactyla; Attenuated strain; Ungulata; Comparative study; Humoral immunity; Inactivated strain
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/S0378-1135(96)00070-3

A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) marker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle. The attenuated vaccine induced the best clinical protection as evidenced by the total absence of clinical signs and fever in cattle. In addition, the attenuated vaccine reduced the shedding of challenge virus significantly more than the inactivated vaccines. Of the inactivated vaccines, the gE-negative vaccine induced a better clinical protection than the gD-subunit vaccine.