Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throu...

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Published in:Frontiers in aging neuroscience Vol. 6; p. 245
Main Authors: Birbrair, Alexander, Zhang, Tan, Wang, Zhong-Min, Messi, Maria L, Mintz, Akiva, Delbono, Osvaldo
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 18-09-2014
Frontiers Media S.A
Subjects:
Aging
Angiogenesis
Bone growth
Endothelial cells
Fibrosis
Growth factors
Innervation
Medicine
Musculoskeletal system
Neuroscience
Ossification (ectopic)
Osteogenesis
Pericytes
Regeneration
Skeletal muscle
Stem Cells
United States > US
regeneration
angiogenesis
pericytes
fat formation
fibrous tissue
aging
innervation
skeletal muscle
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Summary:Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Edited by: Ander Izeta, Instituto Investigación Sanitaria Biodonostia, Spain
Reviewed by: Aurel Popa-Wagner, University of Medicine Rostock, Germany; Marni Della Boppart, University of Illinois at Urbana-Champaign, USA; Cesare Gargioli, University of Rome Tor Vergata, Italy
This article was submitted to the journal Frontiers in Aging Neuroscience.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2014.00245