Antibody Responses to Haemophilus influenzae Type b Vaccines in Men with Human Immunodeficiency Virus Infection

• Published in: The New England journal of medicine Vol. 325; no. 26; pp. 1837 - 1842
• Main Authors: Steinhoff, Mark C, Auerbach, Barry S, Nelson, Kenrad E, Vlahov, David, Becker, Rebecca L, Graham, Neil M.H, Schwartz, David H, Lucas, Alexander H, Chaisson, Richard E
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 26-12-1991
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - immunology; Adult; AIDS; AIDS Vaccines - immunology; AIDS/HIV; Antibodies, Bacterial - analysis; Antibody Formation; Antibody response; Bacterial Vaccines - immunology; Biological and medical sciences; CD4 antigen; CD4-Positive T-Lymphocytes; Diphtheria; Diphtheria Toxoid - immunology; Enzymes; Haemophilus Infections - prevention & control; Haemophilus influenzae; Haemophilus influenzae - immunology; Haemophilus Vaccines; HIV; HIV Infections - immunology; Human immunodeficiency virus; Humans; Immunization; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Leukocyte Count; Lymphocytes; Male; Medical sciences; Random Allocation; Vaccines; Human; Immunopathology; Immune response; AIDS; Vaccine; Haemophilus influenzae; Infection; Pasteurellaceae; Antigen; Prevention; Viral disease; Risk factor; Bacteriosis; Bacteria
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199112263252603

PERSONS with human immunodeficiency virus (HIV) infection have elevated rates of disease caused by the encapsulated bacteria
Streptococcus pneumonias and Haemophilus influenzae}
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The annual incidence rate for
H. influenzae
pneumonia was 42 per 1000 in a prospective study of HIV-seropositive intravenous drug users who did not have the acquired immunodeficiency syndrome (AIDS)
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; a retrospective study of a largely homosexual population with AIDS reported an attack rate of 24 per 1000.
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Most of these retrospective reports do not describe the serotypes of the
H. influenzae
isolated; in two, the authors state that two of three and one of four isolates . . .