Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese

• Published in: Carcinogenesis (New York) Vol. 28; no. 9; pp. 2036 - 2040
• Main Authors: Sugimoto, Mitsushige, Furuta, Takahisa, Shirai, Naohito, Kodaira, Chise, Nishino, Masafumi, Ikuma, Mutsuhiro, Sugimura, Haruhiko, Hishida, Akira
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-09-2007; Oxford Publishing Limited (England)
• Subjects: Aged; Angiotensinogen - genetics; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Cell Division; Confidence Intervals; DNA - blood; DNA - genetics; DNA - isolation & purification; DNA, Neoplasm - blood; DNA, Neoplasm - genetics; DNA, Neoplasm - isolation & purification; Female; Gastroenterology. Liver. Pancreas. Abdomen; Genotype; Helicobacter Infections - complications; Helicobacter Infections - epidemiology; Helicobacter Infections - pathology; Helicobacter pylori; Human bacterial diseases; Humans; Infectious diseases; Japan - epidemiology; Male; Medical sciences; Middle Aged; Odds Ratio; Pepsinogen A - blood; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Asia; Japan; Genetic variability; Spirillales; Spirillaceae; Genotype; Risk; Malignant tumor; Prohormone; Stomach cancer; Epidemiology; Infection; Renin angiotensin system; Helicobacter pylori; Risk factor; Angiotensinogen; Bacteriosis; Digestive diseases; Bacteria; Gastric disease
• ISSN: 0143-3334; 1460-2180
• DOI: 10.1093/carcin/bgm074

Backgrounds and aims: The renin–angiotensin (RA) system including angiotensinogen (AGT), angiotensin I and angiotensin II influences the regulation of cell proliferation, angiogenesis and inflammation. AGT-20 A/C polymorphism is associated with the plasma AGT and angiotensin II levels. The aim of this study was to clarify the association of AGT-20 A/C polymorphism with susceptibility to gastric cancer and peptic ulcer in Japanese. Methods: We assessed the AGT-20 A/C polymorphism in Helicobacter pylori-positive patients with gastric cancer (n = 135), gastric ulcer (n = 148) and duodenal ulcer (n = 113) and controls (n = 292) consisting of H.pylori-positive gastritis alone (n = 160) and H.pylori-negative subjects (n = 132). Results: The age- and sex-adjusted odds ratios (ORs) of AGT-20 A/C and C/C genotypes relative to A/A genotype for gastric cancer risk were 1.695 [95% confidence interval (CI): 1.035–2.777] and 2.259 (95% CI: 0.351–14.533), respectively. The AGT-20 C allele increased the gastric cancer risk (OR: 1.685, 95% CI: 1.037–2.736), especially the intestinal type of gastric cancer (OR: 1.792, 95% CI: 1.040–3.089). However, there was no association between the AGT-20 polymorphism and susceptibility to peptic ulcer. Conclusions: The carriage of AGT-20 C allele was associated with an increased risk for H.pylori-related gastric cancer development in Japanese, indicating that the RA system plays an important role in the pathogenesis of gastric cancer.