FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study

Highlights • Four FKBP5 SNPs were associated with PTSD symptom severity in military veterans. • FKBP5 SNPs interacted with childhood abuse to predict PTSD symptoms. • FKBP5 may be most strongly implicated in expression of PTSD hyperarousal symptoms.

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Bibliographic Details
Published in:	Psychoneuroendocrinology Vol. 69; pp. 98 - 105
Main Authors:	Watkins, Laura E, Han, Shizhong, Harpaz-Rotem, Ilan, Mota, Natalie P, Southwick, Steven M, Krystal, John H, Gelernter, Joel, Pietrzak, Robert H
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2016
Subjects:	Adult Alleles Child Child Abuse - psychology Childhood abuse Endocrinology & Metabolism FKBP5 Gene environment interaction Genetic Predisposition to Disease - genetics Genotype HPA axis Humans Hypothalamo-Hypophyseal System - metabolism Linkage Disequilibrium Male Pituitary-Adrenal System - metabolism Polymorphism, Single Nucleotide - genetics Posttraumatic stress disorder Psychiatry Risk Factors Stress Disorders, Post-Traumatic - genetics Stress Disorders, Post-Traumatic - psychology Substance-Related Disorders - genetics Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Veterans - psychology Childhood abuse Posttraumatic stress disorder HPA axis FKBP5 Gene environment interaction
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Summary:	Highlights • Four FKBP5 SNPs were associated with PTSD symptom severity in military veterans. • FKBP5 SNPs interacted with childhood abuse to predict PTSD symptoms. • FKBP5 may be most strongly implicated in expression of PTSD hyperarousal symptoms.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.04.001