Ameliorative effect of scutellarin on acute alcohol brain injury in mice

• Published in: Journal of Zhejiang University. B. Science Vol. 23; no. 3; pp. 258 - 264
• Main Authors: Zhang, Tianmeng, Wang, Kun, Fan, Hui, Yang, Qiankun, Zhang, Xiao, Liu, Feixue, Feng, Xin, Chen, Yi, Teng, Daoyang, Zhao, Panpan, Dong, Jingquan
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 15-03-2022; Springer Nature B.V; Jiangsu Key Laboratory of Marine Bioresources and Environment,Co-Innovation Center of Jiangsu Marine Bio-Industry Technology,Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,Jiangsu Ocean University,Lianyungang 222005,China%Department of Laboratory Medicine,the Second People's Hospital of Lianyungang City,Lianyungang 222000,China%Jiangsu Key Laboratory of Marine Bioresources and Environment,Co-Innovation Center of Jiangsu Marine Bio-Industry Technology,Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,Jiangsu Ocean University,Lianyungang 222005,China; Key Laboratory of Zoonosis of Ministry of Education,College of Veterinary Medicine,Jilin University,Changchun 130062,China
• Subjects: Biomedical and Life Sciences; Biomedicine; Brain injury; Correspondence; Head injuries; 灯盏花乙素; 酒精性脑损伤; 氧化应激; 炎症; Scutellarin; Oxidative stress; Inflammation; Alcohol brain damage
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.B2100763

Drinking culture has high significance in both China and the world, whether in the entertainment sector or in social occasions; according to the World Health Organization's 2018 Global Alcohol and Health Report, about 3 million people died from excessive drinking in 2016, accounting for 5.3% of the total global deaths that year. Oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse (Snyder et al., 2017). Scutellarin, a kind of flavonoid, is one of the main active ingredients extracted from breviscapine. It exerts anti-inflammatory, antioxidant, and vasodilation effects, and has been used to treat cardiovascular diseases and alcoholic liver injury. Although scutellarin can effectively alleviate multi-target organ injury induced by different forms of stimulation, its protective effect on alcoholic brain injury has not been well-defined. Therefore, the present study established an acute alcohol mice brain injury model to explore the effect of scutellarin on acute alcoholic brain injury. The study was carried out based on the targets of oxidative stress and inflammation, which is of great significance for the targeted therapy of clinical alcohol diseases.